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KMID : 0363320020230010033
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Journal of Korean Oriental Internal Medicine
2002 Volume.23 No. 1 p.33 ~ p.39
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The Effects of Samsoeum Extracts on Regional Cerebral Blood Flow and Blood Pressure in Mice
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Park Byong-Min
Lee Si-Hyeong
Hong Jae-Eui
Ko Young-Chul
Shin Jo-Young
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Abstract
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Objective : The objective of this study is to measure the changes of regional cerebral blood flow(rCBF) and blood pressure(BP) in rats with the following injection.
Methods : The measurement was continually monitored by laser-doppler flowmeter-Transonic Instrument, USA- and pressure tranducer(Grass, USA) in anesthetized adult Sprague-Dawley rats about for two hour to two hour and a half hours through the data acquisition system composed of Maclab and Macintosh computer.
Result : This experiment with Samso-eum increased the changes of rCBF in rats, significantly, but did not change the blood pressure. The rCBF of Samso-eum decreased by pretreated propranolol, and was not changed by pretreated L-NNA and ODQ.
Conclusion : It is considered that the dosage-dependent increase on rCBF is mediated by adrenegic {beta}-receptor.
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KEYWORD
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Samso-eum, rCBF, adrenegic {beta}-receptor
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